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Unlocking the Health Secrets of DNA Repair

DNA damage, genome integrity and disease risk

DNA repair is fundamental to life. Failing to launch DNA repair in the right place at the right time compromises genome stability, which in turn can lead to a wide range of devastating human diseases, including cancers and developmental disorders. Emerging evidence also implicate DNA repair as a key process that underlies learning and memory, highlighting the diverse roles of DNA metabolism in brain and cognitive sciences.

As such, research in DNA repair mechanisms advances our understanding of the molecular bases of genome instability-associated human syndromes. Indeed, not only does DNA repair research aid in disease risk assessment, it also provides invaluable insight in rational drug design and discovery, as exemplified by the recent development of PARP inhibitors as promising therapeutics for the treatment of BRCA-related breast and ovarian cancers.

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Contact Us

 

L1-45, Laboratory Block
21 Sassoon Road
Pokfulam
Hong Kong SAR

 

(852) 3917 6868

huenlab@hku.hk

Selected publications

2021

Dong C, An L, Yu CH, Huen MSY. A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Res. 2021 Feb 22;49(3):1485-1496. doi: 10.1093/nar/gkaa1290. PMID: 33469661; PMCID: PMC7897492.

2017

An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS. Dual-utility NLS drives RNF169-dependent DNA damage responses. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2872-E2881. doi: 10.1073/pnas.1616602114. Epub 2017 Mar 21. PMID: 28325877; PMCID: PMC5389323.

2007

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 2007 Nov 30;131(5):901-14. doi: 10.1016/j.cell.2007.09.041. Epub 2007 Nov 20. PMID: 18001825; PMCID: PMC2149842.

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RESEARCH GOAL:

Defining DNA damage detection and repair processes by identifying key players and events that drive genome integrity protection.

– Michael Huen

Professor, School of Biomedical Sciences

LKS Faculty of Medicine
The University of Hong Kong